A newly published study reveals that overexpressing 15-hydroxyprostaglandin dehydrogenase (HPGD) in triple-negative breast cancer (TNBC) affects tumor growth in a cell line-specific manner, suggesting novel, non-enzymatic roles for HPGD beyond its known function in degrading prostaglandin E2 (PGE₂).
Tumor Regulatory Effect of 15-Hydroxyprostaglandin Dehydrogenase (HPGD) in Triple-Negative Breast Cancer
Joselyn Padilla 1, Bok-Soon Lee 1 2, Allen Kim 1, Yea-In Park 1, Avani Bansal 1, Jiyoung Lee 1 3
Affiliations Expand
PMID: 40076539 PMCID: PMC11899648 DOI: 10.3390/ijms26051912